⌛ Genetics: Positive And Negatively Influence Our Lives

Friday, September 10, 2021 2:44:32 AM

Genetics: Positive And Negatively Influence Our Lives



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How Genetic Applications Affect Our Daily Lives

Alarm calls were raised about the lower birth rates among white Protestant Americans compared to the large immigrant Catholic populations of Italian and Irish descent. German scientists and policymakers visited the United States to learn from their methods, and when the Nazis came to power in Germany, they began eugenic policies of their own. Early German policies called for involuntary euthanasia of people in institutions whose physical or mental illnesses were considered incurable. The Nazis also encouraged selective breeding for Aryan traits e. This policy quickly expanded to include bans on marriage between particular groups, forced sterilization, and then internment in concentration camps for individuals belonging to groups deemed inferior i. Yet many of the same practices and beliefs continued under a different guise.

California had the highest rate of involuntary sterilizations, which were widely performed on prison inmates, people in mental institutions, and women considered to be bad mothers. Such sterilizations were motivated by both perceived individual and social goods, but had deep-seated prejudice as well as scientific inaccuracies built into their assumptions Stern Given the availability of in vitro fertilization, women could now choose to reproduce with men presumed to have high-quality genes, without needing to form relationships with them. Although most Nobel prizewinners proved reluctant to donate to the sperm bank, the general idea took off. Individuals or couples who require gamete donation to reproduce can shop around for a donor who meets their criteria.

The widespread practice of prenatal genetic testing traditionally through chorionic villus sampling or amniocentesis in the second trimester of pregnancy, but now more routinely done through non-invasive blood tests in the first trimester, at least as a first screen , similarly presents the opportunity for individuals or couples to identify genes or genetic markers for traits they prefer for their fetuses not to have. If prenatal testing identifies an undesired gene, prospective parents may choose to continue the pregnancy, or to abort the fetus, often with the plan to later attempt a new pregnancy.

With the advent of pre-implantation genetic diagnosis, prospective parents can choose to use in vitro fertilization, and then test early cells of the created embryos to identify embryos with genes they prefer, or prefer to avoid. In this way, they avoid the potential need for abortion by choosing to implant only embryos that contain the desired genes. The aim of this practice certainly appears eugenic, though without an obviously coercive structure, and for the benefit of the individual family. The profession of genetic counseling, started in the s, provides prospective parents with detailed information about the meaning of the tests, and the opportunity for discussion of test results.

That tenet of genetic counseling has been challenged by scholars who argue that we ought to balance parental autonomy with the child's future autonomy see, e. Finally, advances in genetic technology suggest the possibility that our ability to test for if not manipulate directly a much larger array of genes and genetic markers related to a wide variety of diseases and traits may be on the near horizon. Prenatal testing panels currently include attention to conditions such as Trisomy 13, Trisomy 18, Trisomy 21 Down Syndrome , Tay-Sachs, and more.

Yet we allow adults to be tested for genetic markers linked to late onset disorders such as breast cancer, Huntington's disease, and Alzheimer's disease. Should such genetic tests be available on prenatal testing panels if parents request them? Or for all prospective parents who request prenatal testing? What about other additions that might be of interest to particular parents, even if the genetic linkages to the particular traits are less direct or even only mildly predictive: diabetes, obesity, homosexuality, or psychiatric conditions such as bipolar disorder or schizophrenia?

Informative discussions of the expansion of genetic testing can be found in Davis and Botkin Deciding how to deal with the vast array of potentially genetically-linked markers—as a society, and potentially as individual prospective parents—is a monumental task that requires clarity about the benefits and drawbacks of testing, and requires us to revisit the meaning of eugenics, and the problems associated with it. A much simpler and more clearly linked trait of interest is chromosomal sex. In the United States, parents can choose to find out their fetus's chromosomal sex via amniocentesis, or through an increasing number of early first trimester blood tests. In the U. One of the concerns raised by critics of sex selection is what Mary Ann Warren deemed gendercide, in her book of the same name Warren Indeed, evidence from around the world suggests a relatively strong bias in favor of male children South Korea is now an exception , or at least male children first Davis China and India, countries where cultural norms and practices still decidedly favor men, are facing significant sex ratio imbalances as a result of the use of technologies and non-technical practices such as infanticide to select against girls for a discussion, see Davis Chapter 5.

Concerns about the uses of sex selective technologies against a background of unjust sexism see Bayles ; Rogers et al. As this short history should make clear, past, state-run, involuntary eugenic endeavors have been unjust and socially disastrous. Yet certain practices that have eugenic features continue today, albeit framed differently. Prenatal testing and preimplantation genetic diagnosis, for instance, are understood to enhance patient choice and expand prenatal knowledge, even as they are clearly used by prospective parents to determine which individuals should come into existence.

Should they be considered eugenic practices? Is that necessarily morally troubling? As technological advances push us to figure out how many more, if any, kinds of genes and genetic markers we ought to be able to test for or choose prenatally, we may need to reassess our current practices to explore their justifications, and sort through the ways in which they are eugenic and potentially morally troubling.

Advocates of liberal eugenics intend to distinguish it from troubling historical predecessors by highlighting four main differences. First, it is individual in nature rather than state-sponsored. Second, it is premised on individual liberty, the freedom of parents to choose according to their own values and conceptions of the good life. The state does not mandate contraception, sterilization, prenatal testing, abortion, or any other form of eugenic intervention note: there are potential exceptions in which judges or states have offered long-term contraception such as Norplant as a condition of probation related to a criminal offense or for the continued provision of welfare, see e.

Rather, it allows individuals to choose among a range of alternatives. Third, it presumes value pluralism, recognizing that individual parents will often desire different things for their offspring. This means allowing others to choose in ways that we ourselves would not, in the interest of preserving a liberal society that is neutral about particular conceptions of the good. The aim of a liberal eugenic program is to expand reproductive choices for individuals, in contrast to the historical eugenic programs that clearly cut off reproductive options for many. That said, even liberal eugenics advocates typically presume that some limits would need to be in place, to ensure that prospective parents could not act in ways clearly contrary to the interests of their future children, or in ways that seem clearly vicious; how and where those limits would be set are intensely controversial, as will be discussed below.

Finally, advocates of liberal eugenics highlight the difference between the kind and quality of the science underlying the reproductive policies. Many theorists argue in favor of permitting parents to make choices about their children's genetics, while explicitly arguing against any obligation to improve or enhance their children. Common to these arguments is a presumption that treatment of disease may be obligatory, while enhancement is not. For an excellent discussion of this distinction and its problems, see Parens a.

Liberal eugenics arguments often start by recognizing the value of treatment of disease. Buchanan et al. Parents are obliged to ensure that their children get medical treatment for disease, and can be charged with negligence if they fail to do so. Only diseases that result in relatively small negative effects on participation e. Parents whose conceptions of the good life do not include medical treatment for disease—as in some religious communities—are not allowed to impose this view on their children, because the children deserve the opportunity to choose to adopt those views or not when they are adults.

Mandatory life-saving treatment of their childhood diseases helps to ensure that they survive to make such decisions as adults Feinberg This requirement has been the subject of some debate see, e. If equality of opportunity is one of the aims of a society, then, provision of certain forms of genetic intervention—including interventions that determine who will be brought into existence—may become owed to future people. If parents can decide between implanting an embryo that carries a genetic marker associated with a serious disease— e. To be clear, though, they do not suggest that all prospective parents would be obliged to seek reproductive counseling and use in vitro fertilization in order to fulfill their parenting or impersonal duties.

Such a requirement would be overly demanding on parents and an infringement on their procreative liberty, and would be unlikely to succeed in any case, given the prohibitive costs and relatively low success rates of IVF treatment. Most liberal eugenics advocates Agar ; Glover ; Green move from a commonly accepted position of the requirement to treat serious diseases in children, to a requirement for people using genetic interventions e.

The obligation doesn't extend to mandates on prenatal testing or abortion to avoid giving birth to a child with a serious disease, because of considerations related to women's rights to their bodies and religious freedom. Treatments for disease aside, liberal eugenics advocates recognize that many prospective parents may be interested in enhancing their children. Why settle for the likelihood of normal functioning if one could safely engineer improvements in functioning? At least two reasons lead most such theorists to stop short of advocating a moral obligation to enhance. First, there is the difficulty of determining just what counts as an improvement beyond addressing serious disease. For instance, Agar questions whether it is obviously better for a child to be highly intelligent roughly approximated by a likely IQ of Might some parents reasonably choose a more moderate level of intelligence for a child, presuming he will have greater social opportunities in the latter case?

Perhaps the overall freedom of the child of moderate intelligence will be greater than that of the child with high intelligence, even though on that one dimension his capacities are comparatively lower. The chapters in Parens' edited volume Enhancing Human Traits Parens b point to a variety of ways the enhancement project might be misled by a seemingly valuable target that ends up producing negative effects or undermining other values we cherish. Additionally, even if many people agree on the value of an enhancement and it becomes so common that practically its possession is required for equal participation in society, we might want to resist the temptation to make that intervention obligatory. The now-typical temperament is not a disease, but a mere variety within the capacious normal range of functioning, and would likely remain so even in a future society of 5-HTTLPR-enhanced people.

A liberal eugenics cannot mandate any one view of the good life for its citizens. Still, even mere permissibility to use genetic enhancements raises significant moral concerns. Critics fear obsessively focused prospective parents who design their children in ways that are overbearing or narrowly focused on a particular goal of the parents Kass ; Sandel To avoid this problem, liberal eugenics advocates propose various limits on genetic interventions for enhancement purposes.

There is widespread agreement that interventions should not harm the future child by creating a life so miserable as to be not worth living, as might be the subject of a wrongful life suit. Beyond that, variations include, for instance: 1 only enhancements that will benefit the future children no matter what life plan they decide to pursue and that do not reinforce problematic social norms Agar , or 2 only enhancements that preserve a child's right to an open future Davis , or 3 only enhancements that preserve open futures and protect some central core of our human nature Glover , or 4 only enhancements that rational people will agree can be understood to be in the best interest of the child Green How might one harm a child through choosing genetic traits?

Perhaps by selecting for traits that clearly cause significant suffering and a typically short life span e. Such a requirement may seem a bit unnecessary, given that most parents do not intentionally desire painful states for their children, and would not seek to engineer them in this way. Also, relatively few genetic conditions will be so inherently debilitating as to make life obviously miserable, to the extent that one could not say that life is, on balance, a benefit.

The more contentious territory has to do with choosing between lives that would be worth living, but have different features. How might we ensure a child's capacity to choose from a variety of life plans, or the right to an open future? In other words, if they use genetic interventions in reproduction, they must not use them to narrow the range of options their child will likely have. So parents' choices must not substantively diminish the future options for their children, though they might in some way alter the range or nature of those futures possibilities.

He employs Sen's capabilities approach, identifying various important human capabilities that individuals ought to have, and can then decide whether or not to exercise as they pursue their chosen life plans. Davis and Agar both point to deafness as a useful case for clarification. If hearing is a core human capacity, or even if it is simply necessary for a wide variety of life plans, then engineering a child to be deaf will limit that child's future options. This is not, of course, to say that deaf individuals cannot live rewarding lives in which they flourish.

One might still wonder whether their method of reproducing should even count as an enhancement technology for Agar, given that had one of the women simply partnered with the deaf man, the genetic deafness of their child would not be an issue of engineering. Davis, too, acknowledges the claims of Deaf culture, and the reasons parents might prefer to have a child more like themselves, but argues that deliberately trying to conceive a child who will have relatively limited options—limited, in her view, not just due to enduring discrimination and social constraints, but also to bodily deficits—is morally impermissible. He argues that parents are allowed to. Following William Ruddick, he thinks of parents as both guardians and gardeners —protecting their children so that they can grow as they will, but also shaping how they grow in line with the parents' hopes.

If parents want a child with a good shot at an athletic career, for instance, why not allow them to engineer for athleticism or great vision? Doing so might narrow other life opportunities, but not to the extent that the child couldn't choose how his life goes. His future would still be open enough. Green emphasizes parental reproductive autonomy, and the continuum between shaping the future possibilities for our existing children through parental values, education, religion, and more, and doing so through genetic interventions.

Although he acknowledges the possibility that. Green's central recommendation, then, is that genetic interventions should be aimed at what is reasonably in the child's best interests , recognizing that the parents' own interests are also relevant. Children's future options can, of course, be limited due to the makeup of their bodies, or to the unwelcoming or oppressive social situations into which they are born, or both. Given the history of eugenics, most liberal eugenics advocates recognize the need to attend carefully to unjust social circumstances and to control for existing bias. For instance, if we could change a child's future sexuality through genetic intervention, it might appear that we should permit parents to engineer in either direction, because heterosexuality and homosexuality both permit the successful pursuit of a wide variety of life plans.

But if we attend to current social situations, we will recognize that homophobia is still common in many quarters, despite advances in anti-discrimination legislation and improvements in at least some conscious attitudes, and people who identify as homosexual are more likely to experience social ostracism, bullying, and physical assault. As such, engineering a homosexual child might appear to decrease a child's future options in this society. Thus, if we take the social situation into account, we would only allow engineering to create heterosexual children. Parents who are free to choose characteristics for their offspring may be inclined to choose similarly, either because they agree perhaps wrongly that those characteristics are better, or because they worry their child will be at a substantial disadvantage relative to other children if they choose what is unpopular or simply fail to intervene to ensure what is popular.

If so, societal pressures on parental choices will have effects similar to policies enforced by a state—homogeneity of traits selected across the population. Davis shares this kind of concern, but focuses more on sex selection than selection in respect to sexual orientation. One way to address this problem is to note that some characteristics will only be harmful to the individual in a morally defective social environment, while others will be harmful regardless of the environment e. In the first case, we seem to misdiagnose the problem if we think altering the genome will help address it. What we need to do instead is change attitudes and social practices.

In the second case, however, he argues that the condition itself deafness limits options for the child, even if we can recognize some of the disadvantages of the condition to be social. We might nevertheless think it could be permissible to use genetic engineering to address social problems, if the genetic interventions are at hand and would reduce some suffering, and the social solutions are distant and rather unlikely. For instance, Agar acknowledges that it would be preferable to eliminate racism , but given how entrenched it is in many societies, he considers whether we might want to allow some genetic interventions e. Ultimately, however, he claims that we should not allow this kind of genetic engineering—not simply because it seems to collude with a morally defective social environment, but because it reinforces and perhaps exacerbates that environment it undermines work toward changing the morally defective social environment — Green also recommends against interventions that would reinforce or increase unjust inequality and discrimination, economic inequality, or racism — , but he does so with some reservations.

Parents understandably might want to reduce social burdens on their children through genetic interventions, and if we make doing so illegal, they will likely go elsewhere or underground to get what they want. He also—optimistically—suggests that stereotypes and fashions ebb and flow, and may be self-corrective For instance, Glover defends the permissibility of parental choice within some limits, but he investigates just what counts as a disability. Thus, although racism results in social disadvantage, having dark skin is not itself a disability, because it has no associated functional limitation. Some conditions previously considered disabilities—e. If an individual prefers a bodily state that might otherwise count as a functional limitation his example is Asperger's syndrome , then it isn't a disability for her 14 ; it doesn't affect her flourishing.

He is much less sanguine about blindness and deafness. Both conditions, he suggests, confer significant functional limitations, and although they can certainly allow individuals to have lives of great worth and flourishing—he explores conflicting first person accounts about going blind and gaining sight to explore the positive sides of the conditions and the negative side of normalizing 15—22 —he concludes that they are nonetheless disabilities that confer clear disadvantages related to navigation, safety, etc. As such, they can be understood to be disabilities that are understandably acceptable to some, but that ought not be chosen for future children.

Such future children, like their parents, might be able to flourish with the condition, but engineering it means intentionally impairing at least some capacities commonly relevant to flourishing. Interestingly, Glover concludes that the Deaf lesbian couple who sought a deaf sperm donor did nothing wrong in conceiving their deaf child the child cannot be harmed by his clearly worthwhile existence , but he argues they would be wrong in not giving him a cochlear implant if the technology were perfected Glover's attention to the difficulty of defining disability is helpful, and he emphasizes the importance of taking seriously the perspectives of people who have lived with the disabilities in question. Such first person accounts are, however, but one source of information about the relative value of the condition in question.

A different sort of societal harm that might follow from the permissibility of genetic enhancement is increasing polarization between people who have the finances to afford genetic enhancements, and those who do not. The wealthy already have advantages; if we allow them to give their children genetic enhancements—such that they are smarter, faster, stronger, and with less need to sleep, etc.

One way to avoid the problem would be to attempt to make genetic enhancements available to all, at least for enhancements that offer significant advantages Buchanan Traits that only offer positional advantages—being taller than, perhaps faster than—would then be self-defeating Buchanan et al. Other traits—perhaps enhanced concentration, memory, or immunity—might be advantageous regardless of how many people have them. Providing funding to improve accessibility would then be necessary in order to ensure fairness. Many proponents of liberal eugenics treat the threat of polarization as a relatively minor concern.

For example, Green notes that all innovations have a period of diffusion, during which early adopters pay higher prices and take some risks for the potential of leading the way forward, and then, if the technology is successful, prices drop and the wider public gains access through the market. In Beyond Humanity , Buchanan compares genetic intervention to literacy, numeracy and agriculture: these innovations were only available to a few at the start, but that does not take away from their great benefits to humanity. What might that be? Not simply all the functional states we currently have—those could well change over time, perhaps for the better. Nonetheless, Glover proposes two potential features of great value in our current nature: our capacity to rein in our violent and destructive tendencies, and our capacity to aim for a good life for Glover, this is about a balance between happiness and flourishing.

These are very tentatively offered, with many qualifications about possible linkages to other traits of value, and the likelihood that we might be more successful in securing containment through non-genetic means. Still, the suggestion is that if parents might be tempted to select for genetic markers linked to, for instance, extreme selfishness or emotional coldness, in an attempt to have their child succeed in gaining power and riches, doing so would seem to endanger parts of our nature that we can widely agree are deeply valuable for society as a whole.

Therefore, on Glover's view, even a liberal eugenics should exclude such choices. In sum, theorists who argue for the permissibility of genetic enhancement emphasize the need to protect the future child's options, so long as doing so does not reinforce unjust social prejudices or threaten deeply held core values. At the same time, they seek to preserve parental reproductive autonomy, and to expand rather than reduce parental options. One problem with this thesis, to be explored more in depth below in the section on critiques, is the appropriate scope of its central claims.

Some critics e. If we ought not collude with and exacerbate the social prejudices of sexism and racism through our reproductive genetic choices, why is doing the same for ableist norms permissible? The cynical critic might wonder if there are, in fact, any traits that will meet the criteria for being relatively all-purpose enhancements Sparrow b; Trommelmans Other critics express concern about the meaning and value of relative freedom, particularly when identifying what counts as a decrease in freedom seems to depend significantly on the positioning and values of the particular prospective parent or cultural community Sparrow For him, that single word changes the fundamental assumptions about how and why genetic interventions are pursued.

Liberal states remain neutral about what constitutes the good life, but impose certain restrictions laws, policies and offer education or aid public health campaigns, food stamps in the name of ensuring that citizens are safe, relatively stable, and have equal opportunity to pursue their goals. But critics point out the many ways that a collection of individual choices, pressured by unjust social norms and assumptions, may lead to results not wholly unlike those of historical eugenics programs Duster They fear that regulations put in place by advocates—whether in the form of laws, restrictions of the use of federal or state funds, or mere recommendations or guidelines from medical societies—will not be sufficient to avoid the negative consequences of eugenic enhancement.

Groups who have experienced significant discrimination over many generations will understandably reject such optimism. Such groups have more to fear, however, from those who do not merely argue for permission to enhance, but for an obligation to do so. Other advocates of liberal eugenics e. Some such enhancements might be relatively minor, while others might be radical enough to eventually create a new species Glover These arguments for the obligation to enhance tend to arise in the context of consequential moral reasoning, but with a libertarian qualification. According to early work by Savulescu, for instance, parents have an obligation to produce the best children possible, but the state need not indeed, should not legally coerce them to do so Savulescu To the contrary, the state must balance the benefits of potential enforcement against its existing obligations to protect reproductive liberties.

Nonetheless, the state might have good reason to encourage parents to take such action, through education and persuasive campaigns not unlike anti-smoking campaigns. On this stronger view, others, too, would be right to express disapproval:. Egregious procreative choices deserve our disapproval just like other failures to meet one's obligations, such as failure to protect the welfare of one's children. Kahane and Savulescu A similar position is advocated by Harris Although the arguments are about a moral obligation to enhance, the authors recognize that other competing priorities e.

Savulescu's early paper on the obligation to intervene genetically argued for a seemingly perfectionist stance—if we decide to reproduce, we are morally obligated to have the best children we, as parents, can have. This obligation can't be owed to any particular child given the non-identity problem , but is an impersonal obligation, to make the world a better place. If parents are using pre-implantation genetic diagnosis, they should always choose the embryo with the best chances at the best life. If our best genetic information suggests that one embryo has a chance of mild asthma, and the other does not, and they are alike in other respects, Savulescu claims it is obvious that the parents should choose the embryo not inclined to asthma.

He also offers a much longer list of traits that may have genetic markers, including bipolar disorder, alcoholism, aggression and criminal behavior, memory and intelligence, neuroticism, and maternal behavior Even if these are not all disease-genes, they are linked to conditions that can positively or negatively influence how a life will go. Savulescu imagines that the rational parent could make no other decision but to avoid the negative linkages and promote the positive ones, where possible. Deciding which traits are positive, and of those, which are better than others, is a task that will not be simple. Critics point to the difficulty of ranking the expected well-being of future possible lives, given 1 disagreement about what is positive and negative and the need to contextualize that in a particular environmental and family situation , and 2 the reality that most embryos will have a complex mixture of positive and negative traits making meaningful pairwise comparisons very difficult de Melo Martin ; Parker Kahane and Savulescu reply that we do this kind of ranking all the time, and that it needn't rely on a single vision of what a perfect child would be.

If different forms of life are equally good, or if the amount of well-being realized in each is incomparable, then parents can reasonably choose either option. But there are plenty of cases where we can rank the goodness of lives. We do so in numerous moral decisions in everyday life, especially in bringing up and educating our children. While this response suggests some greater flexibility in their view than might be apparent from the language of PPB, they do not always seem consistent in advocating for this flexibility. How will we know when different forms of life are equally good or when the associated well-being is incomparable?

With the average adult worldwide spending two hours a day on social media and the average American teenager spending up to nine hours a day , research estimates that social-media addiction now affects almost half a million people globally. But just how bad is social media for our mental health? In doing so, it exploits our human desire for the connection to and validation of others, giving us a dopamine hit every time we get a like or reply without ever actually fulfilling our deep human needs. This can lead, as the documentary argues, to a whole host of negative emotions, which drive us back to social media for that quick fix. As such, social media becomes a kind of digital pacifier, a maladaptive coping strategy used whenever we feel lonely, uncomfortable, or sad.

But are our concerns misplaced? Mental illness rates in high-income countries are on the rise, and this is correlative with increased social-media use—but correlation does not necessarily equal causation. It is highly influenced by what we do on it and why we do it, not just the time we spend. Where some studies have found occasions when social-media use can contribute to poor mental health, others have found there to be no effect, while some have even found evidence to support the idea that it can improve mental health, possibly by reducing loneliness and improving self-esteem. In the absence of physical interaction, we have learned new virtual languages—sharing texts, memes, and emojis—with friends, family, and colleagues that can only serve to better our collective mental health.

COVID aside, social media has been pivotal in connecting like-minded people. Indeed, we must be more critical when generalizing about social-media use: 20 minutes chatting with friends on Facebook Messenger is not the same as 20 minutes looking at distressing content. One of the most worrying effects of social media, as outlined in The Social Dilemma, is its negative impact on our body image. Research is relatively consistent in finding a correlation between this and social media, especially when consuming and engaging with appearance-focused content that promotes narrow societal beauty standards.

Move Genetics: Positive And Negatively Influence Our Lives mouse over the green Genetics: Positive And Negatively Influence Our Lives to see the gene names. These different responses largely have to do with differences in genetics. Oliver likewise highlights the trick of labeling gender a morally neutral category in a world filled with sexism, Genetics: Positive And Negatively Influence Our Lives also rightly Verbonia Case Study the levels of surveillance Genetics: Positive And Negatively Influence Our Lives control over women TD Bank, Americas Most Convenient Bank are likely to Genetics: Positive And Negatively Influence Our Lives the implementation of liberal eugenics. Cancer Cell. Econs - Thaler and Sunstein's term for the 'imaginary' people whom most leaders and politicians believe typify Genetics: Positive And Negatively Influence Our Lives i.

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